The tissue adhesive Histoacryl®

The tissue adhesive Histoacryl® consists of monomeric n-butyl-2-cyanoacrylate, which polymerizes quickly in connection with tissue fluid. Histoacryl® is available in two colors: translucent, special for facial application blue, which enables an easy control over the quantity applied in different indications approved. Indication: Skin Closure: Closure of skin wounds without tension (including clean surgical incisions and incisions from minimally invasive surgery), and simple, thoroughly cleansed, trauma-induced lacerations. Sclerotherapy: Sclerotherapy of large esophageal or fundal varices. Mesh fixation: Fixation of hernia meshes, especially in inguinal hernia surgery. Advantages Skin closure Decreased skin closure time compared to sutures [1-8] Microbial barrier action [9-12] Less pain than suture materials is expected [2] Only 30 seconds of holding the wound edges are needed [13] Storage at room temperature <22 ºC [13] Sclerotherapy Indicated for bleeding esophagogastric varices and as a secondary prophylaxis in varices that have previously bled [14-39] Final hemostasis is achieved in >90% of cases [14-16], [18], [20], [21], [24], [32], [34], [36-41 In gastric varices lower rebleeding rate than with band ligation is expected [17], [18], [20], [21], [27], [40-42] Mesh fixation Similar recurrence rate than with traditional fixation methods [43-51] Stand-alone fixation method in different hernia repair techniques [43-47], [49-52] Atraumatic method reported to be better tolerated by the patient than traditional fixation methods [43-49], [51], [52] Low or similar intra- and postoperative morbidity compared to traditional fixation methods. [43], [45], [48], [49], [51] Reduced risk of post-operative chronic pain compared to traditional fixation methods [43-49], [51] Decreased surgery time compared to traditional fixation methods [45-48], [50] Faster return to work compared to traditional fixation methods. [43], [45], [50], [53] Lower or similar rate of infections related to Histoacryl than other techniques [43], [45-48], [54] Only necessary to apply few small drops to the desired fixing sites. [55] Can be used in laparoscopic and open hernia repair procedures. [46-53], [56-62]